Inside Dolomite Labs: Polystyrene particles synthesis


Microfluidic methods for the synthesis of monodisperse polystyrene particles 

Polystyrene is a synthetic polymer widely used for the synthesis of ordered materials, biomedical tests, particle size standards, and column packing. In recent years, monodisperse polystyrene microspheres have been increasingly present in the field of microelectronics acting, for example, as conductive particles in anisotropic conductive film. The Dolomite Team has been working on developing a methodology for the synthesis of highly monodisperse polystyrene beads via droplet microfluidic methods using either UV or thermal curing.


polystyrene particles

Figure 1. Polystyrene beads on a glass slide – 50 µm in diameter.

Figure 2.  Polystyrene beads produced in a Dolomite Telos® 2 Reagent Chip SC – 50 µm in diameter.


Chip used:

Telos® 2 Reagent Chip SC

Droplet phase:

  • Styrene 20%
  • Divinylbenzene (DVB) 80%
  • Initiator: thermal (AINB 1%) or UV based (4-(Dimethylamino) benzophenone 1%)

Continuous phase:



Styrene/DVB droplets were generated using a Telos chip to establish the system capability to produce on-spec droplets and determine the maximum production rate.  Two different curing methods were investigated: UV and thermal curing.


UV curing

The emulsion coming out of the droplet generating chip was collected into a 20 mL glass vial containing 10 mL of the continuous phase. The vial was subsequently exposed to the UV light for 15 min.


Thermal curing

The emulsion coming out the chip was fed into a long PTFE tube providing a residence time of 10 min. The tube was immersed in an oil or a water bath and kept at a constant temperature of 80 °C. The resulting particles were then transferred into a vial and kept at the same temperature to complete the curing process.

As a result of this experiment, the Dolomite Team has established a methodology for the high-throughput production of polystyrene particles varying in size from a few up to hundreds of microns.


If you are interested in producing monodisperse polystyrene beads for your application, please contact us via our contact form or at