Research into efficient and effective drug delivery systems is important in the development of medicines and the future of a personalized approach to treatments. Being able to encapsulate a drug for controlled release has advantages including lower dosage, reduced side-effects, and improved results of the treatment.
Dolomite’s continuous flow, microfluidic method overcomes these obstacles, providing almost 100% encapsulation within precisely controlled, monodisperse PLGA particles, in a reproducible way.
For drug encapsulation to be effective, it’s important that the size, shape, and architecture of the particle is precise and reproducible.
Conventional methods however often result in uneven API distribution and particle polydispersity.
Create smaller particles across a wider range of sizes. Using the traditional batch method results in uneven API distribution and particle polydispersity. This then requires size-selection, leading to low particle yields, wastage and significant loss of API.
A dolomite microfluidic system is helping Dr Samar Damiati, Assistant Professor in Biochemistry Department at King Abdulaziz in Saudi Arabia, perform drug encapsulation studies.
Methodology for fabrication of monodisperse PLGA beads with sizes ranging from 50 nm to 30 µm using the Hydrodynamic Flow Focusing Method.
Methodology for fabrication of highly monodisperse PLGA beads with sizes ranging from 10 µm to 30 µm using the Droplet Method.