Research into efficient and effective drug delivery systems is important in the development of medicines and the future of a personalized approach to treatments. Being able to encapsulate a drug for controlled release has advantages including lower dosage, reduced side-effects, and improved results of the treatment.

Dolomite’s continuous flow, microfluidic method overcomes these obstacles, providing almost 100% encapsulation within precisely controlled, monodisperse PLGA particles, in a reproducible way.

 

SPEAK TO AN EXPERT

Monodisperse and uniform particles

For drug encapsulation to be effective, it’s important that the size, shape, and architecture of the particle is precise and reproducible. 
Conventional methods however often result in uneven API distribution and particle polydispersity.

  • Small average size and narrow size distributions
  • Monodisperse (CV 5%)
  • Uniform morphology

Microfluidics vs traditional methods

Create smaller particles across a wider range of sizes. Using the traditional batch method results in uneven API distribution and particle polydispersity. This then requires size-selection, leading to low particle yields, wastage and significant loss of API.

Traditional methods (Batch)  Microfluidic methods
Encapsulation efficiency ~30% ~5%
Particle size distribution ~20% ~5%
Waste ~50% Near 0%
Reproducibility Low High
API mixing Uneven Uniform
Particle size control Poor Precise

Microfluidic applications & methods

Application notes

Continuous microfluidic synthesis of PLGA nanoparticles

Methodology for fabrication of monodisperse PLGA beads with sizes ranging from 50 nm to 30 µm using the Hydrodynamic Flow Focusing Method.

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Continuous microfluidic synthesis of PLGA nanoparticles

Continuous microfluidic synthesis of PLGA microparticles

Methodology for fabrication of highly monodisperse PLGA beads with sizes ranging from 10 µm to 30 µm using the Droplet Method.

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Continuous microfluidic synthesis of PLGA microparticles

Recorded webinars

RECORDED WEBINAR | JULY 2018

Learn how to produce PLGA nanoparticles!

This webinar introduced novel Dolomite’s microfluidic methods of precisely controlled PLGA nanoparticle production.

RECORDED WEBINAR | DECEMBER 2018

Learn how to encapsulate hydrophilic API in PLGA!

This webinar explored most suitable microfluidic methods of encapsulating hydrophilic active pharmaceutical ingredients (API) in PLGA particles.

RECORDED WEBINAR | SEPTEMBER 2018

Learn how to encapsulate hydrophobic API in PLGA!

This webinar explored how microfluidic encapsulation of hydrophobic active pharmaceutical ingredient (API) in PLGA particles works.

microfluidic drug api microencapsulation systems

System solutions

Dolomite’s Drug (API) Encapsulation Systems are the perfect solution for this pharmaceutical applications as they utilize microfluidic methods to directly generate monodisperse particles, bead and emulsions, eliminating the need for further processing. They can be used to generate particles in nano and micro size range, resulting in formulations such as water in oil (w/o) or oil in water (o/w) emulsions.

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Further reading

Developing microfluidic routes to effective nanoparticle drug delivery systems
Testimonials

Developing microfluidic routes to effective nanoparticle drug delivery systems

A Dolomite Microfluidics’ set-up is helping researchers in the University of Manchester’s Division of Pharmacy and Optometry to enhance PLGA drug delivery systems for oncology applications, and liposomes for the co-delivery of fat- and water-soluble therapeutics.

Inside Dolomite Labs: PLGA Multiple Emulsions for Hydrophilic Drug Delivery
FEATURED STORIES

Inside Dolomite Labs: PLGA Multiple Emulsions for Hydrophilic Drug Delivery

The Dolomite Team is using the microfluidic multiple emulsions methodology to encapsulate PLGA for hydrophilic drug delivery.

Fluorescent biosensors as tools for drug therapeutics
TESTIMONIALS

Fluorescent biosensors as tools for drug therapeutics

Read about how researchers in the School of Pharmacy at the University of Nottingham have been using Dolomite Microfluidic’s chips to enhance their work on drug encapsulation and therapeutic delivery.

Want to know more about drug encapsulation?