Research into efficient and effective drug delivery systems is important in the development of medicines and the future of a personalized approach to treatments. Being able to encapsulate a drug for controlled release has advantages including lower dosage, reduced side-effects, and improved results of the treatment.

Dolomite’s continuous flow, microfluidic method overcomes these obstacles, providing almost 100% encapsulation within precisely controlled, monodisperse PLGA particles, in a reproducible way.

 

SPEAK TO AN EXPERT

Microfluidic applications

Monodisperse and uniform particles

For drug encapsulation to be effective, it’s important that the size, shape, and architecture of the particle is precise and reproducible. 
Conventional methods however often result in uneven API distribution and particle polydispersity.

  • Small average size and narrow size distributions
  • Monodisperse (CV 5%)
  • Uniform morphology
Microfluidics vs Traditional Batch Methods

Larger size range with a narrow distribution

Create smaller particles across a wider range of sizes. Using the traditional batch method results in uneven API distribution and particle polydispersity. This then requires size-selection, leading to low particle yields, wastage and significant loss of API.

Microfluidics vs traditional methods

Traditional methods (Batch)  Microfluidic methods
Encapsulation efficiency ~30% ~5%
Particle size distribution ~20% ~5%
Waste ~50% Near 0%
Reproducibility Low High
API mixing Uneven Uniform
Particle size control Poor Precise

Further reading

Drug delivery studies
Testimonials

Drug delivery studies

A dolomite microfluidic system is helping Dr Samar Damiati, Assistant Professor in Biochemistry Department at King Abdulaziz in Saudi Arabia, perform drug encapsulation studies.

Continuous microfluidic synthesis of PLGA nanoparticles
Application Notes

Continuous microfluidic synthesis of PLGA nanoparticles

Methodology for fabrication of monodisperse PLGA beads with sizes ranging from 50 nm to 30 µm using the Hydrodynamic Flow Focusing Method.

Continuous microfluidic synthesis of PLGA microparticles
Application Notes

Continuous microfluidic synthesis of PLGA microparticles

Methodology for fabrication of highly monodisperse PLGA beads with sizes ranging from 10 µm to 30 µm using the Droplet Method.

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