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Developing an advanced microfluidic method for manufacture of taxane-loaded nanoparticles for cancer treatment

 

Researchers at the University of Porto, Portugal are using Dolomite Microfluidics chips to manufacture diverse therapeutic nanoplatforms, including an advanced microfluidic method for manufacture of taxane-loaded nanoparticles for cancer treatment.

 

PhD Student Cláudia Martins: “Our recent publication in Methods in Molecular Biology1 describes an advanced microfluidic method for the continuous manufacturing of multitargeted, taxane-loaded nanoparticles of modified polymers of PLGA and PEG. Taxanes play a key role in the treatment of various types of cancer, and these nanoparticles are a promising strategy to enable their formulation while offering the potential to pave the way towards multitargeted treatments with fewer side effects and maximum therapeutic benefit. The protocol focuses on setting up the microfluidic system using a Dolomite chip and optimization of the method conditions required to manufacture the taxane-loaded nanoparticles. The microfluidic method developed allows the reproducible production of large-scale batches of these nanoparticles with lower polydispersity and a higher drug load in a more effective, time-saving manner. The taxane-loaded nanoparticles were manufactured using polymers of PLGA and PEG that had been chemically modified with cancer-targeted moieties as part of my PhD project.”

 

Cláudia Martins (PhD student) and Prof. Bruno Sarmento.

 

Prof. Bruno Sarmento: “We first came into contact with Dolomite in 2017, and since then we have explored the potential of its microfluidic chips to manufacture diverse therapeutic nanoplatforms. Dolomite’s microfluidic chips have greatly helped the progress of the core research areas of our group, involving cancer, infection and metabolic diseases.”

 

  1. Martins C., Sarmento B. (2020) Microfluidic Manufacturing of Multitargeted PLGA/PEG Nanoparticles for Delivery of Taxane Chemotherapeutics. In: Jain K. (eds) Drug Delivery Systems. Methods in Molecular Biology, vol 2059. Humana, New York, NY.

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