Developing an advanced microfluidic method for manufacture of taxane-loaded nanoparticles for cancer treatment


Researchers at the University of Porto, Portugal are using Dolomite Microfluidics chips to manufacture diverse therapeutic nanoplatforms, including an advanced microfluidic method for manufacture of taxane-loaded nanoparticles for cancer treatment.

PhD Student Cláudia Martins: “In our protocol, recently published at Methods in Molecular Biology, we have described an advanced microfluidic method for the continuous manufacturing of multitargeted, taxane-loaded nanoparticles of modified polymers of PLGA and PEG. Taxanes play a key role in the treatment of various types of cancer and these nanoparticles are a promising strategy to enable their formulation, while offering the potential to pave the way towards multitargeted treatments with less side effects and maximum therapeutic benefit. The protocol is focused on the setting up of the microfluidic system using a Dolomite chip and optimization of the method conditions required to manufacture the taxane-loaded nanoparticles. The developed microfluidic method allows the production of large-scale batches of these nanoparticles with lower polydispersity, higher drug loading, reproducibility and in a better time-saving manner. The taxane-loaded nanoparticles were manufactured using polymers of PLGA and PEG that has been chemically modified with cancer-targeted moieties under the scope of my PhD project.”


Cláudia Martins (PhD student) and Prof. Bruno Sarmento.


Prof. Bruno Sarmento: “We first came in contact with Dolomite in 2017, and since then we have explored the potential of their microfluidic chips to manufacture diverse therapeutic nanoplatforms. The microfluidic chips of Dolomite have greatly helped the progress of the core research areas of our group involving cancer, infection and metabolic diseases.”


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