The next generation is here The Automated Nanoparticle System provides a flexible & efficient modular platform for protocol development Change my world LNP production just got easier Flexibility to set up multi-scale experiments with easy parameter adaptions Show me how The future of vaccine &
drug development
Generate samples for library screening and process optimization, narrowing down timescales Tell me more

Providing a modular platform for protocol development and formulation library generation. 

Dolomite presents a next-generation system dedicated to protocol development and production of a wide range of nanoparticle types including liposomes, lipid nanoparticles and more. Tailored and scalable, it facilitates library generation for formulation screening allowing you to progress through the protocol development pipeline without the need to change your entire system. 

 

SPEAK TO AN EXPERT

Slide AUTOMATION Run subsequent experiments and produce screening-ready libraries for quicker protocol optimisation.
SHOW ME HOW
Slide ENCAPSULATION EFFICIENCY Produce NPs with >95% encapsulation efficiency using microfluidics.
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Slide COST SAVING Preserve your precious cargo by using the system’s low-volume operation mode. HELP ME SAVE Slide FLEXIBILITY Tailor the modular system to your application & build upon in the future. TELL ME MORE Slide PRECISION Achieve acute control and reproducibility to optimise your protocol development.

TAKE MY NPS TO THE NEXT LEVEL

Liposome and Lipid Nanoparticle Synthesis

The ability to produce monodisperse liposomes and lipid nanoparticles with narrow size distribution and acutely control the reproducibility is crucial for the scientific and pharmaceutical communities. Within the fields of targeted drug delivery and controlled drug release, parameters like particle size can affect the rate of drug uptake and clearance, which emphasises the need for a robust, scalable fabrication process. Batch techniques typically result in a reduction of control over the synthesis process, leading to wide particles size distributions and, in some cases, to uncontrolled particle aggregation. 

By contrast, microfluidic encapsulation methods have demonstrated the potential for achieving higher control over the physical properties of the final nano-lipid or liposome product than conventional batch methods. Typical microfluidics characteristics, such as low Reynolds number and diffusion dominated mass transfer, make it the most viable method for producing lipid-based nanoscale vesicular systems with the potential for clinical application.

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Introduction to the Automated Nanoparticle System

System specifications

Particle size

Particles ranging from 40 nm to 800 nm.

Particle monodispersity

Extremely monodisperse with PDI ≈ 0.1 – 0.2.

Sample volume Min sample volume 200 ul; the valve allows accurate collection of the sample with the option to extract the heart cut – the central cut of the sample. Continuous mode of operation allows the production of larger sample volumes.
Automation

The system allows the creation of protocols, which can: 

  • calculate the volume required for the entered FRR
  • correct the timing ensuring correct reagent convergence in the chip
  • collect correct sample volume using the Automated Sample Valve
  • wash and prime the system
  • run multiple experiments with one load
Flexibility

The modular system can be paired with a range of glass chips, syringes and sample loops to be tailored to your specific application.

Chemical resistance

Very high (wetted materials: glass, PEEK, ETFE, FEP, PTFE).

 

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Further reading

Flyer

 

Ready to take your nanoparticle generation process to the next level? Read our flyer to learn how Dolomite can help you minimize the cost and optimize your protocols quicker.

Download flyer

Validation Data Pack

 

Still not convinced? Discover our Validation Data Pack describing how the System works and presenting the experimental data gathered by Dolomite’s Experts. 

Download Validation Data Pack

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Lipid Delivery Systems for Nucleic-Acid-Based-Drugs: From Production to Clinical Applications

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mRNA vaccine delivery using lipid nanoparticles

Interested to learn more about this system? 

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