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Biological Sciences

Publication

Formulation and Optimization of Repaglinide Nanoparticles Using Microfluidics for Enhanced Bioavailability and Management of Diabetes

Authors: Mubashir Ahmad, Shahzeb Khan, Syed Muhammad Hassan Shah, Muhammad Zahoor, Zahid Hussain, Haya Hussain, Syed Wadood Ali Shah, Riaz Ullah and Amal Alotaibi

Published year: 2023

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Produce nanocrystals to improve bioavailability of an antihyperglycaemic drug. Nanocrytals had a much lower IC50 than the tablet form, and higher efficacy than other drugs

Publication

FACS-Based Functional Protein Screening via Microfluidic Co-encapsulation of Yeast Secretor and Mammalian Reporter Cells

Authors: Desislava Yanakieva, Adrian Elter, Jens Bratsch, Karlheinz Friedrich, Stefan Becker & Harald Kolmar

Published year: 2020

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Successfully enriched 1:10000 dilution of secreting yeast cells. Used 2 rounds of encapsulation of agarose (water) in oil, FACS sorting after emulsion breaking

Publication

Xdrop: Targeted sequencing of long DNA molecules from low input samples using droplet sorting

Authors: Esben B. Madsen, Ida Höijer, Thomas Kvist, Adam Ameur, Marie J. Mikkelsen

Published year: 2020

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Introducing Xdrop technology, a novel microfluidic-based workflow for targeted enrichment of long DNA molecules

Publication

Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis 

Authors: Bernhard Strauss, Andrew Harrison, Paula Almeida Coelho, Keiko Yata, Magdalena Zernicka-Goetz, Jonathon Pines

Published year: 2018

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Cyclin B1 is essential for embryo development, but its role in mitosis was unclear. In this study, large numbers of mouse embryos were cultured in a custom microfluidic chip, and imaged before recovering for genotyping. They found that Cyclin B1 is an essential regulator of the cell cycle

Publication

A monolithic glass chip for active single-cell sorting based on mechanical phenotyping

Authors: Christoph Faigle, Franziska Lautenschläger, Graeme Whyte, Philip Homewood, Estela Martín-Badosa and Jochen Guck

Published year: 2015

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Showing the utility of a custom glass-stretcher chip through measuring and and sorting single cells by their mechanical properties in a heterogenous population

Chemistry

Publication

Autonomous electrochemical system for ammonia oxidation reaction measurements at the International Space Station

Authors: Camila Morales-Navas, Roberto A. Martínez-Rodríguez, Francisco J. Vidal-Iglesias, Armando Peña, Joesene J. Soto-Pérez, Pedro Trinidad, José Solla-Gullón, Toshko Tzvetkov, Jonathan Doan, Eugene S. Smotkin, Eduardo Nicolau, Juan M. Feliu & Carlos R. Cabrera

Published year: 2023

Field: Chemistry

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Ammonia has potential in in-situ resource utilization for NASA space missions, as it is a high energy molecule that can be converted to nitrogen and electrical energy via the ammonia oxidation reaction. In this proof of concept, a small scale AOR setup was taken to the ISS, and achieved positive results, opening the door to future scaled-up experiments

Publication

Freezing of micro-droplets driven by power ultrasound

Authors: Shaolei Gai, Zhengbiao Peng, Behdad Moghtaderi, Jianglong Yu, Elham Doroodchi

Published year: 2022

Field: Chemical engineering

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Studying the effects of system parameters on the freezing of droplets. The study revealed important data for the formation of small spherical ice droplets

Publication

Application of microfluidics to control product selectivity during non-catalytic oxidation of naphthenic-aromatic hydrocarbons

Authors: M. N. Siddiquee A. de Klerk and N. Nazemifard 

Published year: 2016

Field: Organic chemistry – petrochemicals

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Analysis of the liquid phase oxidation behavior of a simple naphthenic-aromatic hydrocarbon. Increasing oxygen availability in the microreactor. Ketone-to-alcohol sensitivity increased with oxygen availability.

Publication

High throughput production of microcapsules using microfluidics for self-healing of cementitious materials

Authors: Lívia Ribeiro de Souza and Abir Al-Tabbaa

Published year: 2021

Field: Engineering

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Capsules with a liquid core present a promising solution for self-healing cementitious materials. Microfluidics allow for precise control over size and thickness using double emulsions. Here, production was scaled up with a high-throughput microfluidic system