Microfluidic Systems

Dolomite offers a range of high performance modular microfluidic systems for production of precision engineered droplets, emulsions, double emulsions, bubbles and complex particles. The ultimate smooth flow and size control are designed to produce highly monodisperse droplets ranging from only few nm up to 500 µm in diameter. These innovative systems are used in a wide range of applications in biology, drug discovery and delivery, chemistry, food, cosmetics and academia.

Showing all 11 results

  • + Drug (API) Encapsulation Systems

    Drug (API) Encapsulation Systems

    Encapsulate an API in PLGA particles

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    Drug (API) Encapsulation Systems

    The Drug Encapsulation System provides a complete solution for encapsulating an API in PLGA particles.

    PLGA is used to encapsulate drugs because they can be easily metabolized and allow controlled release of the drug over time. The particles can also be coated to increase their blood circulation life. Specific ligands and antibodies can be grafted on the particle surface to target specific sites for drug release. With Dolomite systems, users can efficiently generate particles depending on the size and characteristics required by your application. Specific features of the Dolomite system include:

    • High chemical, thermal, and pressure resistance
    • Capable of high flow rates and operation with viscous fluids
    • Safe pressure vessel design to eliminate the risk of vial fracture in operation 
    • Scalable to high throughput and scale up to kg per day with no waste
    • Flexible with vacuum and pressure capability in same pump
    • Compact set-up as single channel pumps contain integrated reservoir

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  • + Micro Droplet Generation Systems

    Micro Droplet Generation Systems

    Produce up to 500,000 monodisperse droplets / second

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    Micro Droplet Generation Systems

    Droplet Generation Systems offer a solution for production of mono-dispersed droplets for a wide range of general laboratory research applications.

    Dolomite’s modular droplet generation systems apply flow focusing microfluidic methods for small (from 2 to 40 µm) and large (from 20 to 200 µm) water in oil (W/O) or oil in water (O/W) droplet production.
    Whilst microfluidic methods offer a wide range of applications, our droplet generation systems are designed to produce droplets made up of one, two or three reagents. This may benefit user focused on generation of monodispersed droplets, emulsions and Janus particles. Systems enables rapid advances in droplet microfluidics allowing users to produce up to half a million monodispersed droplets per second. Thanks to their modularity, Droplet Generation Systems provide users with a very cost-effective scale up. Specific features of systems include:

    • Stable and pulseless liquid flow
    • Highly monodispersed droplets ranging from 2 µm to 200 µm
    • Production rate of up to 500,000 droplets per second
    • Flexible system for easy scale-up (Telos Large Scale Micro Droplet System)
    • Modular and adjustable to suit applications

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  • + Liposome Systems

    Liposome Systems

    Systems for liposome synthesis and drug encapsulation

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    Liposome Systems

    Dolomite’s Liposome Systems offer a solution for nanoliposome synthesis.

    Dolomite’s modular liposome systems apply microfluidic hydrodynamic focusing (MHF) approach for the synthesis of small (from 50 to 500 nm) liposome vesicles. The interest in synthetic methods of liposome production using microfluidic techniques is ever increasing. The vesicular structure of liposome particles enables encapsulation of both hydrophilic and hydrophobic pharmaceutical drugs and nutrients.

    Dolomite nonoliposome system has been specifically designed for the continuous formation of liposome nanoparticles, and offers consistent performance, particle reproducibility, long life, and ease of use. In addition, its modularity provides users with a very cost-effective scale up. Specific features users can expect include:

    • High product yield
    • Precise particle reproducibility
    • High chemical resistance
    • Highly monodispersed liposomes particles ranging from 50 nm to 500 nm
    • High-throughput scalability, up to 1L per day (Telos Large Scale Micro Droplet System)
    • Reduce reagent consumption
    • Ability to tune the particle size

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  • + Nanoparticle Generation System

    Nanoparticle Generation System

    Produce highly monodispersed polymer particles

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    Nanoparticle Generation System

    The Polymer Nanoparticle Generation System provides a solution for production of monodisperse polymer nanoparticles such as PLGA, PEG, PVC.

    Dolomite’s modular nanoparticle synthesis systems apply high shear micromixing and hydrodynamic focusing microfluidic methods for polymer particle production ranging in sizes from 50nm to 500nm. Continuous and controllable laminar flow allows the production of high-yield and high-quality polymer nanoparticles. The system provides substantial improvements in nanoparticle size distribution when compared to conventional batch methods. Additional benefits include:

    • Wide range of particle sizes ranging from 50 nm to 500 nm
    • Highly monodisperse particles with CV values between 20% and 30%
    • Precise control of size, shape and morphology of particles
    • Production rate up to few grams per day (Telos Large Scale Micro Droplet System)
    • Batch to batch reproducibility with reduced reagent consumption
    • Modular systems
    • Easy scale-up for various applications

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  • + Educational Microfluidic System

    Educational Microfluidic System

    Low cost systems for new-starters in microfluidics. Generate droplets, visualise flows in micro channels and learn more about microfluidics.

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    Educational Microfluidic System

    Dolomite's Educational Microfluidic Starter System is a perfect solution to explore core microfluidic principles and technologies.

    The modular starter system offers hands-on understanding of microfluidics in a convenient, cost effective and very flexible way. The aim is to introduce and emphasize microfluidic concepts such as laminar flow and diffusion, and allow practical learning of methods for droplet generation, mixing of fluids or monitoring of fluid flow. Plus, provide all data users will need to grasp the understanding of microfluidics.

    The Starter system is an ideal tool for practical lab teaching sessions. For example, students can design experiments to test the effect of flow rate on diffusional mixing, setup the equipment, run the experiment, and capture images for their lab reports.

    An easy to use microfluidic compact system can be a perfect solution for busy laboratories too. The ability to use small fluid volumes means that hazardous fluids can be used in a controlled way. This helps not only to track experimental protocols or procedures, but also promote the utilisation of microfluidics at an earlier stage of research.

    • Ideal for education and those new to microfluidics
    • Ability to form small droplets, mix fluids, or observe microchannel flow
    • Easy investigation of a wide range of microfluidic applications
    • Inexpensive solution for proof of concept analysis
    • Very modular for easy portability
    • Flexibility to use a wide range of glass chips, your own PDMS chips, or even design, print and test your own 3D printed prototypes (using Dolomite's unique Fluidic Factory)

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  • + Telos Large Scale Micro Droplet System

    Telos Large Scale Micro Droplet System

    Scale-up droplets, emulsions and particles production to up to tons per month

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    Telos Large Scale Micro Droplet System

    Built around Dolomite's revolutionary Telos® high-throughput microfluidic platform, the Large Scale Droplet Production Systems provide a complete solution for scaling-up droplet, particles or emulsion manufacturing, allowing users to seamlessly produce large quantities of monodispersed droplets of various sizes.

    • Up to 70 microfluidic channels producing droplets in parallel
    • 1 set of pumps for feeding all parallel channels
    • Pulseless and stable liquid flow
    • Highly monodispersed droplets ranging from 20 µm to 150 µm
    • Production rate of up to 500,000 droplets per second, comparable to those achieved by traditional batch methods
    • Modular and adjustable to user needs

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  • + Double Emulsions Systems

    Double Emulsions Systems

    Generate oil-water-oil or water-oil-water emulsions

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    Double Emulsions Systems

    The advanced Dolomite Double Emulsion Systems give users the possibility to generate highly monodisperse water-in-oil-in-water (w/o/w) or oil-in-water-in-oil (o/w/o) droplets. The versatile systems can be set-up for a one-step or a two-step double emulsion process, depending on the application. They allow precise control over droplet size, production rate, as well as volume ratios of inner and outer droplets. 

    • Reproducible and consistent production of double emulsions
    • Highly monodispersed droplets
    • Flexible system suitable for generating both w/o/w and o/w/o double emulsions in various sizes
    • One-step or two-step process achievable on the same system
    • Easy to set up and use
    • Modular to suit your application

    See our dedicated Applications webpage to learn more about Double Emulsions.

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  • + Porous Media System

    Porous Media System

    Monitor and visualize fluid flow through porous media

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    Porous Media System

    The Porous Media System is ideal for study and modelisation of liquid flows in porous rocks. This microfluidic system is centered around a Porous Media Chip which simulates complex porous rock structure and enables full visualization and easy monitoring of fluid flow.

    • Gain a better understanding of the displacement mechanisms in porous media
    • Fast, reproducible and robust testing
    • Safe and easy-to-use system with no tools required
    • Wide temperature and pressure operating ranges
    • Excellent chemical compatibility
    • Great access for optics for easy visualization
    • Custom porous media structures available

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  • + Droplets on Demand – Dropix

    Droplets on Demand – Dropix

    Generate complex sequences of unique droplets by varying size, inter-space and content

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    Droplets on Demand – Dropix

    Based on the proprietary Mitos Dropix® technology, the Droplets on Demand System is a novel, compact and portable system. It is designed for easy generation of extremely miniaturized droplets with excellent control over volume, environment and isolation of contents. This compact off-chip droplet generator enables users to create combinatorial droplet arrays from several different samples and store up to 1000 droplets with various sizes on a storage coil.

    • Utmost flexibility: choose the droplet volume size, frequency and content
    • Use multiple reagents to create complex assays quickly and easily
    • Generate up to 5 droplets per second, with sizes down to 50 nL, from 24 different sample wells in any sequence
    • Ability to pre-program commands for automated droplet collection via an easy-to-use PC software user interface 
    • Several possible operating modes: droplet generation, droplet merging, droplet splitting
    • Small footprint, very easy to set up, no tools required

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  • + Rapid Microfluidic Prototyping – Fluidic Factory

    Rapid Microfluidic Prototyping – Fluidic Factory

    3D Printer for fast and inexpensive prototyping of sealed microfluidic devices using COC

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    Rapid Microfluidic Prototyping – Fluidic Factory

    Dolomite's Fluidic Factory is the world's first commercially available 3D printer for rapid prototyping of sealed microfluidic devices. It allows you to design your own microfluidic devices, manifolds, connectors (or select designs from the existing design library) and get printing in minutes. Fluidic Factory prints cyclic olefin copolymer (COC), a bio-compatible, optically transparent and robust polymer.

    • Inexpensive prototyping method: cost per device typically ranges from few dollars to several tens of dollars
    • Manufacture microfluidic devices in one single step: no cleaning or post processing required
    • Print small devices in 1 hour, larger devices under a day: faster than stereolithography (SLA), injection molding, or micromilling
    • Rapidly print 10s or 100s of low cost, disposable devices
    • Fluidic Factory uses COC  - a translucent, hard, biologically compatible polymer
    • Very easy to use: from CAD to print in minutes
    • Winner of the prestigious R&D100 Award 2016

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  • + Flow Chemistry Systems

    Flow Chemistry Systems

    Affordable and flexible flow chemistry

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    Flow Chemistry Systems

    The Dolomite Flow Chemistry Systems are easy-to-use, affordable, modular systems for a variety of flow chemistry applications.

    The systems allow multiple configurations for lab scale reactions and are upgradable for more functionality. The systems offer a wide range of reaction parameters with flow rates from 1 µL/min to 10 mL/min and temperatures from 1 °C to 250 °C.

    Sophisticated flow chemistry experiments can be performed with precise control of reaction parameters, residence time, reaction temperature and stoichiometry as well as reagent introduction. Coupled with the intuitive PC control software, Flow Control Centre Advanced, reactions can be automated with accuracy and reproducibility.

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