Dolomite Support Tips: Time for a Spring Clean
23rd August 2018
By its very definition, microfluidics manipulates fluids working below the milliliter range. Typically, this uses tubing and/or chips which have features ranging from 800 µm to the smallest chip we’ve produced at 0.2 µm. Dust particles, ranging in size from a few nanometres to the millimeter range, are found almost ubiquitously in nature. Fibers/hairs are also found universally and can be transferred through normal contact when handling equipment. Each source of contaminant has the potential to interrupt microfluidic experiments, but there are methods to mitigate and prevent these from occurring.
How do I make PLGA microparticles?
11th July 2018
Drug encapsulation with in polymeric particles, such as poly(lactic-co-glycolic acid) (PLGA), has been common practice for the last 20 years. Until now however, methodologies commonly used to create such particles have been ineffective and wasteful. Conventional batch methods produce particles and beads with a wide range of diameters in each batch, meaning that the specific properties of the beads may vary significantly across the sample. By contrast, microfluidic technologies enable the production of highly monodisperse particles in a single step, thereby increasing the yield of on-specification bead sizes.
Dolomite introduces new specialist chemicals to assist emulsion stabilization
6th July 2018Dolomite Microfluidics now offers a range of specialist chemicals designed to stabilise a variety of emulsions. By forming highly stable and reproducible emulsions, our products enable high retention of droplet contents, rapid rates of droplet formation, as well as controlled emulsion breaking when required.
Methods of diverse API encapsulation in polymer beads
11th June 2018
Until now commonly used encapsulation methods (such as high-shear mixing or sonication) have been ineffective and wasteful. By contrast, droplet microfluidic technology enables high encapsulation efficiency and the fabrication of unique formulations that are difficult or impossible to achieve using standard methodologies. This gives researchers access to variety of formulation that can be fine-tuned depending on the nature of the (API) and specific functional requirements.
Producing polymer particles: An alternative approach to traditional batch methods
13th April 2018
Microfluidics is an ideal tool for applications such as encapsulation of reagents, or other ingredients, when compared with traditional batch methods, due to the ability to produce precisely controlled, monodisperse particles. Here we’ll talk about the benefits of a microfluidic approach in producing monodisperse micro- and nanoparticles in a reproducible and scalable way.