Polymer Particle Synthesis
Microfluidics is an ideal technology for making polymer beads from materials such as PLGA, polystyrene, agarose and alginate. Unlike conventional methods such as homogenization, microfluidic droplet systems enable production of hundreds of thousands of microparticles per second, with very narrow size distribution. It is possible to make particles with controlled size (from 20 nm to 250 µm), shape (spherical, disks or oblate) and morphology (beads, plugs and disks). In addition to simple droplets or particles, multiphase droplets can be produced (e.g. gas filled polymer spheres, Janus particles, and ternary polymer particles).
Dolomite systems and products offer many benefits for polymer beads production:
- Narrow size distribution: microfluidic techniques offer extremely consistent size of particles (e.g. 1 % coefficient of variation)
- Wide range of particle sizes: from 20 nm to 250 µm
- Excellent control: control the size, shape and morphology (beads, plugs and disks)
- Simple or multiphase droplet/particle production: produce simple droplets/particle or gas filled polymer spheres, Janus particles, and ternary polymer particles
- Easy to use: reliable continuous double emulsions production enables industry scale manufacturing
- Reliable and easy to use: all of Dolomite’s products are designed to quickly connect together without the need for tools. Automation is also available
Typically, the particle is first formed as a liquid droplet, and then downstream and subsequent post-processing is used to convert from a liquid phase droplet to a solid phase particle. This phase transition can be achieved using Dolomite systems via one of many strategies – for example: photopolymerization, free radical polymerization, solvent extraction/displacement or melt cooling. A wide range of polymer particles, such as solid, porous, and hollow particles, have been synthesized using these methods, with a well-defined structure and morphology.
In addition to applications for Drug delivery, the particles present a mobile substrate that can then be biochemically tailored – this is known as surface functionalization. The process involves covalent immobilization of proteins, peptides, and nucleic acids to chemical end groups exposed on the surface of the solid microparticles. E.g. Polystyrene microspheres are ideal for protein adsorption.
Affinity binding systems offer simple and efficient ligand attachment. Coatings of Fc binding proteins are able to orient antibodies for optimal activity, and streptavidin offers extremely stable attachment of biotinylated molecules, such as proteins, peptides, and oligonucleotides.
- Diagnostic tests and assays
- Controlled drug release/targeted drug delivery – novel application – generation of biodegradable microparticles
- µ-PIV (Particle Image Velocimetry)
- Biotechnology (separation of DNA)
- Oil-field chemicals – enhanced oil recovery, scale inhibitors
- Binders for paints and varnishes
- Radioactive waste treatments
Nanoparticle Generation System
Produce highly monodispersed polymer particles
- Encapsulate content in polymer particles
- Wide range of particle sizes ranging from nm to 250 µm
- Highly monodisperse particles with CV values as low as 1 %
- Production rate of up to 5 kg/per day
- Batch to batch reproducibility
- Excellent control of size, shape and morphology of particles
- Flexible systems for easy scale-up
Nanoparticle Generation System
Our Polymer Particle Synthesis Systems allow drug encapsulation and production of highly monodisperse micro- and nanoparticles from materials such as PLGA, PEG, PVC, silica, liposomes, and many more. The systems use Dolomite's extensive range of high quality glass chips to precisely make particles with specific diameters with minimum size dispersion.